Timely and accurate information about regional economic conditions can be essential for planning, implementing and evaluating locally targeted economic policies. However, European regional accounts for output are published at annual frequency with a two-year delay. To obtain robust and more timely measures in a computationally efficient manner, we propose a mixed-frequency dynamic factor model that accounts for national information to produce high-frequency estimates and reliable nowcasts of regional gross value added in more than 150 regions across 13 European countries.